BackgroundPatients with COVID-19 may feel under pressure to participate in research during the pandemic. Safeguards to protect research participants include ethical guidelines [e.g. Declaration of Helsinki and good clinical practice (GCP)], legislation to protect participants’ privacy, research ethics committees (RECs) and informed consent. The International Committee of Medical Journal Editors (ICMJE) advises researchers to document compliance with these safeguards. Adherence to publication guidelines has been suboptimal in other specialty fields. The aim of this rapid review was to determine whether COVID-19 (...) human research publications report compliance with these ethical safeguards.MethodsA rapid systematic literature review was conducted in MEDLINE using the search term ‘COVID-19’. The search was performed in April 2020 with no start date and repeated to include articles published in November 2020. Filters were ‘Full free text available’ and ‘English Language’. Two reviewers assessed article title, abstracts and full texts. Non-COVID-19 articles and non-clinical studies were excluded. Independent reviewers conducted a second assessment of a random 20% of articles. The outcomes included reporting of compliance with the Declaration of Helsinki and GCP, REC approval, informed consent and participant privacy.ResultsThe searches yielded 1275 and 1942 articles of which 247 and 717 were deemed eligible, from the April search and November respectively. The majority of journals had editorial policies which purported to comply with ICMJE ethical standards. Reporting of compliance with ethical guidelines was low across all study types but was higher in the November search for case series and observational studies. Reporting of informed consent for case studies and observational studies was higher in the November search, but similar for case series. Overall, participant confidentiality was maintained but some case studies included a combination of details which would have enabled participant identification. Reporting of REC approval was higher in the November search for observational studies.ConclusionsWhile the majority of journal’s editorial policies purported to support the ethical safeguards, many COVID-19 clinical research publications identified in this rapid review lacked documentation of these important safeguards for research participants. In order to promote public trust, ethical declarations should be included consistently. (shrink)

Cet article est l’occasion de rappeler que le numérique, outil de communication aux avantages économiques indéniables, est également un facteur de risques pour les libertés individuelles. Devenu incontournable, le développement du numérique exige une recherche perpétuelle d’équilibre entre attraits économiques et préservation des libertés individuelles. Le lecteur est invité à suivre le point de vue d’un avocat exerçant en droit du numérique, observateur de l’oscillation entre progression des outils numériques enrichis par l’intelligence artificielle et respect des principes qui gouvernent toute (...) société démocratique. (shrink)

Weak states and ineffective economic policies are assumed to mediate the constraints of the world system and to prevent upward mobility among peripheral countries. This article tests the effects of state strength and economic policy on world system mobility in the period 1970–85 on a sample of 162 countries. World system role and mobility were operationalized using role equivalence based network measures. Countries with effective neoorthodox policies experience significantly higher mobility, even after controlling for economic performance, as do countries with (...) states that have high despotic capacity. No effect, direct or indirect, was found for infrastructural state capacity. (shrink)

In a voting context, when the preferences of voters are described by linear orderings over a finite set of alternatives, the Maximin rule orders the alternatives according to their minimal rank in the voters’ preferences. It is equivalent to the Fallback bargaining process described by Brams and Kilgour (Group Decision and Negotiation 10:287–316, 2001). This article proposes a characterization of the Maximin rule as a social welfare function (SWF) based upon five conditions: Neutrality, Duplication, Unanimity, Top Invariance, and Weak Separability. (...) In a similar way, we obtain a characterization for the Maximax SWF by using Bottom Invariance instead of Top Invariance. Then, these results are compared to the axiomatic characterizations of two famous scoring rules, the Plurality rule and the Antiplurality rule. (shrink)

How do gym-goers who are normally not inclined to resort to appearance- and performance-enhancing drugs (APEDs) progressively normalize their use? Based on data collected through a year and a half of participant observation in a gym and thirty semi-directive interviews with practitioners with varying profiles in French-speaking Switzerland, this article examines the evolution of practitioners’ relations with APED use by articulating various levels of analysis. Associated with social vulnerabilities, the progressive normalization of APED use is concomitant with the “conversion” to (...) bodybuilding. Our results show the extent to which and under what conditions interactions within the layout of gyms can influence practices. From refusal to normalization, our results suggest that APEDs and the associated beliefs coincide with career stages, which we aim to bring to light here. (shrink)

With the increased acceptance of complementary and alternative medicine (CAM) within society, new research reflects deeper folk health histories beyond formal medical spaces. The contested relationships between formal and informal medicine have deep provenance and as scientific medicine began to professionalise in the 19th century, lay health knowledges were simultaneously absorbed and disempowered (Porter 1997). In particular, the ‘medical gaze’ and the responses of informal medicine to this gaze were framed around themes of power, regulation, authenticity and narrative reputation. These (...) responses were emplaced and mobile; enacted within multiple settings by multiple agents and structures over time. The work is drawn from secondary material from Ireland, which identify more indigenous narratives of health and act as potential sources for medical humanities. While assumptions have been made as to the place of folk-medicine being essentially rural, evidence will be presented which shows a more complex network of health beliefs and practices. The narratives of informal practice and folk-medicine drawn from evidence from Ireland point to more fluid and hybrid relations with formal medicine and suggest that the complementary nature of the two models reflected wider cultural debates and models of belief (Del Casino Jnr., Health & Place 10:59-73, 2004). (shrink)

Curricular design that addresses residency physician competencies in communication skills and professionalism remains a challenge. Graphic Medicine uses comics, a medium combining text and images, to communicate healthcare concepts. Narrative Medicine, in undergraduate medical education, has limited reported usage in Graduate Medical Education. Given the time constraints and intensity of GME, we hypothesized that comics as a form of narrative medicine would be an efficient medium to engage residents.The authors created a novel curriculum to promote effective communication and professionalism, focusing (...) on empathy, compassion and cultural competency. A four-week curriculum was delivered in a neurology residency program. Excerpts from non-fiction graphic memoirs about neurological conditions were read, discussed, and paired with prompt-driven drawing exercises. Qualitative surveys were used to assess acceptability of comics, usefulness of comics to convey patient illness experience, and perception of patient needs for physician-patient communication.Ninety-seven percent of residents reported the sessions were a good use of their time. Residents identified new symptoms of neurologic disorders, articulated patient communication needs, and expressed increased empathy after participation. Residents participated in drawing exercises, but these were not formally analyzed. Graphic medicine is a well received format that may build communication skills and increase empathy. (shrink)

In ”Skepticism,” Peter Klein distinguishes between the “Academic Skeptic” who proposes that we cannot have knowledge of a certain set of propositions and the “Pyrrhonian Skeptic” who refrains from opining about whether we can have knowledge. Klein argues that Academic Skepticism is plausibly supported by a “Closure Principle‐style” argument based on the claim that if x entails y and S has justification for x, then S has justification for y. He turns to contextualism to see if it can contribute to (...) the discussion between one who claims that we can have knowledge about some epistemically interesting class of propositions and the Academic Skeptic. He outlines the background of Pyrrhonian Skepticism, pointing out that the Pyrrhonist withholds assent concerning our knowledge‐bearing status because reason cannot provide an adequate basis for assent. He assesses three possible patterns of reasoning, and concludes that the Pyrrhonist view, that reason cannot resolve matters concerning the nonevident, is vindicated. (shrink)

Ainslie advances Freud's and Skinner's theories of homunculi by basing their emergent complexity on the interaction of simple algorithms. The rules of competition and cooperation of these interests are underspecified, but they provide a new way of thinking about the basic elements of conditioning, particularly conditioned stimuli (CSs).

In this article I examine Skinner's objections to mentalism. I conclude that his only valid objections concern the "specious explanations" that mentalism might afford ? explanations that are incomplete, circular, or faulty in other ways. Unfortunately, the mere adoption of behavioristic terminology does not solve that problem. It camouflages the nature of "private events," while providing no protection from specious explanations. I argue that covert states and events are causally effective, and may be sufficiently different in their nature to deserve (...) a name other than "behavior."To call such events"mental"does not force a dualistic metaphysics: Such a distinction can be easily assimilated by an "emergent behaviorism." Emergent behaviorism would make explicit use of theories. It would be inductive and pragmatic, and would evaluate hypothetical constructs in terms of their utility in clarifying and solving the outstanding problems of the discipline. (shrink)

As the number of computational models of eye-movement control in reading increases, so too will their coverage and complexity. This will make their comparison and testing increasingly challenging. We argue here that there is a need to develop a methodology for constructing and evaluating such models, and outline aspects of a possible methodology.

In her Behavioral and Brain Sciences target article, Greenfield (1991) proposed that early in a child's development Broca's area may serve the dual function of coordinating object assembly and organizing the production of structured utterances. As development progresses, the upper and lower regions of Broca's area become increasingly specialized for motor coordination and speech, respectively. This commentary presents a connectionist simulation of aspects of this proposal. The results of the simulation confirm the main thrust of Greenfield's argument and suggest that (...) an important impetus for the developmental differentiation in Broca's area may be the increasing complexity of the computational demands made upon it. (shrink)

Selon une analyse très répandue aujourd'hui, la société contemporaine serait caractérisée par une vaste autonomie des acteurs ; pourtant, ce n'est pas parce que l'hétéronomie autoritaire a régressé au cours des dernières décennies que toute forme d'hétéronomie a disparu, ni que l'autonomie s'étend automatiquement à toute la société. Les domaines dans lesquels le terme « autonomie » est actuellement d'usage courant sont multiples et les acceptions scientifiques du concept fort diverses ; est-ce à dire qu'un même mot est employé pour (...) désigner des faits irréductibles entre eux ou bien n'est-il de véritable autonomie que complexe, tant individuelle que collective ? En tout cas, l'autonomie est moins, aujourd'hui, une réalité, qu'un projet de société, à la fois exigeant, limité et novateur. (shrink)

Bioethics needs an expanded moral vision. It is now time for bioethics to take full account of the problems of health disparities and structural injustice that are made newly urgent by the COVID-19 pandemic and the effects of climate change. Nancy M. P. King, Gail E. Henderson, and Larry R. Churchill make the case for a more social understanding and application of justice, a deeper humility in assessing expertise in bioethics consulting, a broader and more relevant research agenda, and greater (...) appreciation of the profound health implications of global warming. (shrink)